Georges, Sire du Trémouille, was brought up at the court of Jean sans Peur of Burgundy whom he accompanied to Paris in 1413. He was named in that same year Grand Chamberlain of Charles VI. Taken prisoner at Agincourt, Georges did not recover his liberty until he paid a high ransom.

He married, in 1416, the very rich and old Jeanne de Boulogne, widow of the duc de Berry, who died about 1423. From 1418 on Georges played the rôle of mediator between Charles VI and the princes. On January 21, 1420, Philip of Burgundy commanded the gens de Comples to grant him the Count of Boulogne to pay feudal homage. Sent on a mission close to the Duke of Burgundy in December, 1425, Georges was arrested at La Charité sur Loire by Perrinet Gressart, the captain who vainly fought against Jeanne d'Arc.

In February, 1427, Georges took possession of Issodoun, where he captured Pierre de Giac, the favorite and minister of Charles VII. Giac was drowned, and his wife Catherine de l'Ile-Bouchard gave to the audacious Georges Giac's jewels and money, and later herself. Thus in July, 1427, the former chamberlain of Jean sans Peur, Duke of Burgundy, this powerful baron whose family belonged to the Burgundian party, came into power as Charles VII's first minister. Georges, moreover, held in his hand the great military lords of that time, and this fat man was able to advance money to King Charles VII who was always in need of it.

After the winning of Beaugency, Jargeau and Troyes, Georges de la Trémouille took part in the coronation at Reims. We know that after the defeat at Paris Jeanne stayed for some time at Trémouille's castle at Sully sur Loire and that this sojourn was in the nature of a semicaptivity.

We know also that in 1433 the Constable du Richemont, who was himself also accused of having forfeited Jeanne's confidence, surprised Trémouille at Chinon. Georges, wounded by a dagger thrust, owed his life to nothing but his fat. He was confirmed in his pensions, but remained alienated from the court and later, at the time of the Dauphin Louis's insurrection against his father Charles VII, Trémouille joined the revolutionists.

He died at Sully on May 6, 1446.